Cisplatin renal function

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August undefined, 2024

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. The alleviation or prevention of CDDP … WebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev. 1995; 21: 33–64GFR (mL/min) Dose60 100%50–60 75%40–50 50%40 AvoidBennett 50 100%10–50 75%

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebNephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate … WebWhat Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, … t shirt tucked in with a belt or out

Risk factors for renal toxicity after inpatient cisplatin ...

WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … WebMar 2, 2024 · To assess the influence of cisplatin on renal function in the short and long terms, we recorded the baseline creatinine level, the maximum creatinine value a few … phils sport arena

Nephrotoxicity and hydration management for cisplatin ... - PubMed

WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute kidney disease, whereas the mechanism of chronic kidney disease after cisplatin chemotherapy is largely unknown. In the present … t shirt tucked into jeansWebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data on the adherence of physicians to dosing recommendations for these drugs in cancer patients with renal impairment. Three … t shirt tucked into high waisted jeans

"WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … " - Cisplatin renal function

Cisplatin renal function

WebApr 9, 2024 · The most common reason for cisplatin-ineligibility is renal function impairment. Up to 40% of patients with bladder cancer have renal impairment, defined …

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WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … WebIt covalently binds to DNA and disrupts DNA function. 6. After cisplatin enters the cells, the chloride ligands are replaced by water molecules. 7,8. ... is a major concern when prescribing cisplatin. Renal dysfunction due to cisplatin may manifest as renal insufficiency, hypokalemia and hypomagnesemia. ...

WebMar 29, 2024 · Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible condition, effects are notably seen years after treatment with cisplatin has ceased. It has an extensive pathophysiological map. The purpose of this article is to consolidate cisplatin-induced acute kidney injury literature and present it in one … WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with …

WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … WebJan 11, 2024 · During and after cisplatin treatment. Renal function should be closely monitored before each dose of chemotherapy every 1–2 weeks.

WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and …

WebSep 1, 2024 · Cisplatin induces multiple intracellular injury pathways, including inflammation, oxidative stress, apoptotic pathways, and DNA damage mediating renal tubular cell injury. phils spa and poolsWebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the … t shirt tucked in with baggy jeansWebAfter my husbands first dose of cisplatin he was put in the hospital with poor kindey function. He was put on a renal diet.. He never received Cisplatin after that, and his kidneys are back to normal. I am curious, I believe your husband has been out of treatment for awhile. So, is this late side effects? buzz99 Member Posts: 404 May 2011 #8 t shirt tucked into skirtWebCisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in patients with impaired renal function. phils spiced lamb kebabsWebMain outcome measure: Cisplatin dose in mg/m(2) based on kidney function and according to the dosing recommendations. Results: Among 1,364 cycles of cisplatin, … phils statsWebApr 14, 2024 · Nicotinamide deficiency has been linked to the damage of the renal tubular cells, especially proximal tubular cells. For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. t shirt tucked into shortsWebFor cisplatin Monitoring of patient parameters Monitor full blood count. Monitor audiology. Monitor plasma electrolytes. Nephrotoxicity Monitoring of renal function is essential. … t shirt tucked into joggers