Cytoplasmic sox10

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August undefined, 2024

WebSOX10. −: − ± ... The cytoplasm is usually amphophilic and granular due to their secretory content. MTCs routinely express neuroendocrine markers as well as signs of thyroid differentiation (TTF1), whereas monoclonal PAX8 expression is lacking, as is thyroglobulin (the latter a consequence of the non-follicular cell origin). ... WebFeb 6, 2024 · We found that Sox10 induced the expression of Fbxo9, which is both required and sufficient for regulating Neurog2 protein stability via ubiquitination that was …

Fbxo9 functions downstream of Sox10 to determine neuron-glial …

WebJul 6, 2024 · In postnatal mice, melanocytes maintain and are maintained by expression of high levels of Sox10, while Sox10 activity in melanocyte stem cells is decreased 38. It is commonly accepted that ... WebSOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens SOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens phoera foundation 104

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WebNov 29, 2024 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and inter … Web方法. 回顾性分析2016年2月至2024年1月上海市肺科医院与复旦大学附属肿瘤医院确诊的5例肺gct的临床资料、病理形态学特征及免疫表型特点，并复习相关文献。 WebAug 27, 2024 · Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural … how do you get rid of serratia marcescens

Immunohistochemical Staining for SOX10 and SDHB in …

Sox10 expression in ovarian epithelial tumors is associated

WebAug 20, 2015 · Results: SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma cases (38/38). HMB-45 showed cytoplasmic positivity in 97.3 (37/38). … WebIn addition, a fourth pattern with cytoplasmic AE1/AE3 and nuclear SOX10 was observed in a subset of carcinomas, most notably triple-negative breast cancers. Conclusions: … how do you get rid of schizophreniaWebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nucleocytoplasmic shuttling activity. An interspecies heterokaryon analysis was performed as originally described by Pinol-Roma and Dreyfuss . how do you get rid of scutigera coleoptrata

"WebJun 20, 2014 · Cytoplasmic staining for the pan-melanoma cocktail and nuclear staining for SOX10 and MITF were scored by 2 pathologists (J.C. and Y.G.). Positive staining in >1% … " - Cytoplasmic sox10

Cytoplasmic sox10

Neurons populating the rectal extrinsic nerves in humans express ...

WebFeb 6, 2024 · The relocalization of ectopic Neurog2 from the nucleus to the cytoplasm suggests the possibility that overexpression of Sox10 promotes ubiquitination of Neurog2, which could occur in both compartments as evidenced by another short-lived bHLH transcription factor, MyoD ( 26 ). WebJan 1, 2014 · (B) Sox10 immunohistochemistry results in diffuse crisp nuclear staining in all granular tumor cells in cutaneous GCTs, 400×. (C) Noncutaneous GCTs from breast (top) and tongue (bottom), as well as other deep tissue sites, also showed diffuse nuclear staining in all granular tumor cells.

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WebAug 11, 2015 · SOX10 was negative in 10 cases of ITACs and 2 cases of non-ITACs, and positive in all other adenocarcinomas. The sensitivity of CK7-, CK20+, SOX10- and CDX2+ in primary ITACs of the sinonasal tract were 70.0%, 90.0%, 100%, 100%, respectively, and the specificity were 100%, 96.8%, 93.5%, 100%, respectively. Conclusions: WebMay 5, 2009 · Others have shown that Sox10 is a nucleocytoplasmic shuttling protein. We extend this observation and demonstrate that, in the cytoplasm, Sox10 is peripherally associated with the mitochondrial outer membrane. Both Sox10 and ARMCX3 are expressed in mouse brain and spinal cord as well as several cell lines. Overexpression …

SOX10 is used as an immunohistochemistry marker, being positive in: • Neuroectodermal neoplasms of neural crest origin, especially: Melanoma, although desmoplastic melanomas may be only focally positive. Nevus • SOX10 immunohistochemistry in a dermal nevus, showing positively stainin… WebDec 3, 2024 · SOX10, located at 22q13.1, has five transcripts (splice variants), 67 orthologs, and 16 paralogs. As a nucleocytoplasmic shuttle protein, SOX10 is of great significance to the development of the neural crest, the peripheral nervous system, and melanocytes ( Castillo and Sanchez-Cespedes, 2012 ).

WebSep 15, 2015 · Whereas SOX10 has a nuclear localisation in the embryonic neural crest, hEPI-NCSC showed predominantly cytoplasmic SOX10 immunoreactivity. WNT and SHH signalling are part of the network that regulates SOX10 expression ( Werner et al., 2007 ; McNeill et al., 2012 ), which explains the increased nuclear SOX10 localisation in hEPI … WebMar 15, 2024 · SOX10 shows an increased specificity for soft tissue tumors of neural crest origin compared with S100 ( Appl Immunohistochem Mol Morphol 2012;20:445 ) MITF1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with …

WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ...

WebFeb 6, 2024 · the cytoplasm of both Fbxo9- and Sox10-expressing cells compared. to predominant nuclear localization of Neurog2 in the vector control (Fig. 4 A and B). In contrast, the number of HuC/D + phoera foundation ebayWebDec 31, 2024 · In ARM, cytoplasmic SOX10 was co‐expressed with neuronal antigens in ~57% of submucosal and myenteric neurons, vs. ~3% in control. Furthermore, intrinsic gut neurons in ARM specimens co‐expressed PLP1 (18%) and CDH19 (18%); however, neuronal co‐expression of PLP1 and CDH19 was rarely (<2%) observed in controls. phoera foundation coupon codeWebJun 19, 2024 · In contrast to S100, which is expressed in both the nucleus and cytoplasm, SOX10 is confined to the nucleus, enabling double staining to be performed on paraffin … phoera baseWebNov 4, 2024 · SOX10 positivity is also commonly expressed in both mixed tumors and myoepitheliomas (~80%), but is only present in a minor percentage of myoepithelial carcinomas (Fig. 3f) . Other markers of ... how do you get rid of shimejisWebJan 10, 2024 · To isolate single Sox10 + /FSP1 − cells from Sox10 + /FSP1 + cells, we plated the mixed cell population at very low density (~100 cells per 100-mm dish), and … how do you get rid of scales on citrus treesWebAbstract. SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been … how do you get rid of shin splintsWebSep 1, 2024 · Ten cases originally diagnosed as OC, and 1 low-grade uncertain oncocytic tumor (11/74) revealed nuclear-cytoplasmic and/or nuclear positivity for S100 protein and/or SOX10, respectively. Fusion transcripts CHCHD7-PLAG1 and GEM-PLAG1 were found in 2 cases (1 fusion in each), and these were confirmed by RT-PCR and PLAG1 … phoera foundation boots