Kif18a cin
Web21 mrt. 2024 · KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include Asbestosis and Goldberg-Shprintzen Syndrome . Among … Web16 jun. 2024 · CIN tumor cells dependent on KIF18A for cellular proliferation also showed a significant increase in multipolar spindle formation and centrosome fragmentation. These …
Kif18a cin
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Web9 sep. 2024 · KIF18A is a mitotic kinesin that regulates chromosome alignment during cell division. Leveraging its proprietary CINtech platform, Volastra discovered that CIN-high … Web1 nov. 2024 · Background KIF18A is a kinesin family member that is involved in various cellular processes including cell division, cell transformation, and carcinogenesis. However, its possible role in the regulation of host immunity has not been examined. Objective The aim of this study is to investigate the functional role of KIF18A in the differentiation and …
Web7 mrt. 2024 · In cancers, KIF18A is central to the proliferation of chromosomally unstable tumor cells. Disrupting the action of this protein could interrupt the process of cell division … Web22 feb. 2024 · KIF18A is required for proliferation of CIN cells derived from triple negative breast cancer or colorectal cancer tumors but is not required in near-diploid cells.
WebKIF18A-dependent CIN lines display a signi cant increase in multipolar spindles compared to non-KIF18A-dependent cell lines (Fig. 4a, b). Multipolar spindles were de ned as spindles Web4 apr. 2024 · Abstract. Chromosomal instability (CIN) is one of the hallmarks of cancer. Cancer cells often undergo whole-genome doubling (WGD) and P53 represents a major barrier to the proliferation of WGD+ cells. Therefore, cancer cells with either CIN or WGD often harbor the p53 mutation. Recently, KIF18A has emerged as a potential therapeutic …
Web11 jun. 2024 · 3.2.Knockdown of KIF18A suppresses cell proliferation, migration, and invading in EC cells. Under the condition that KIF18A levels were significantly downregulated in siKIF18A-transfected Eca-109 and KYSE-150 cells compared with the siCtrl groups confirmed by qRT-PCR (P < 0.0001) (Fig. 1 C) and WB (Fig. 1 D), we …
WebDownload scientific diagram KIF18A depletion increases cell death in CIN cells a Representative images (from three independent experiments) of HT29 and MCF10A cells labeled with Celltox Green ... games that test memoryWeb10 mei 2005 · KIF18A DMDM 66774137 ClinGen HGNC:29441 GenCC HGNC:29441 Expression Induction By estrogen. 1 publication Gene expression databases Bgee ENSG00000121621 Expressed in ventricular zone and 112 other tissues Genevisible Q8NI77 HS Organism-specific databases HPA ENSG00000121621 Group enriched … games that use a dialWeb22 mrt. 2024 · The targets to be partnered do not include Volastra’s lead synthetic lethal target—KIF18A, a mitotic kinesin-8 motor protein shown to play a role in promoting the … games that track your locationWeb16 feb. 2024 · The protein KIF18A is essential for CIN during the proliferation of cancer cells. Interestingly, the knockout of Kif18A in mice only showed minor defects, indicating … games that test cpuWeb27 jan. 2024 · We identified a specific mitotic kinesin, KIF18A, whose activity was perturbed in aneuploid cancer cells. ... Three days of SAC inhibition induced CIN in all lines, ... black haired anime boy with suitWeb8 feb. 2024 · KIF18A belongs to the Kinesin family, which participates in the occurrence and progression of tumors. However, few pan-cancer analyses have been performed on KIF18A to date. We used multiple public databases such as TIMER, The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA) to … black haired anime boy with blue eyesWebKIF18A, a mitotic kinesin, has been shown to play a role in maintaining bipolar spindle integrity and promotes viability of CIN cancer cells. To explore the potential of KIF18A, a … black haired anime boys