WebApr 5, 2024 · LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. Genetic regulation of THBS1 methylation in diabetic retinopathy. PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Dysregulated thrombospondin 1 and miRNA-29a … WebMar 8, 2024 · Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to ...
Entry - *611533 - NUCLEOLAR PROTEIN 7; NOL7 - OMIM
WebMay 29, 2024 · Compared to skin from wild-type mice, skin from Thbs1-/-mice had reduced collagen cross-linking and reduced prolysyl oxidase (proLOX) abundance with increased conversion to catalytically active LOX. In vitro, TSP1 bound to both the C-propeptide domain of collagen I and the highly conserved KGHR sequences of the collagen triple-helical … WebJan 27, 2016 · Infiltration of CD68 + macrophages into liver tissue after ischemia/reperfusion injury was similarly reduced in thbs1 −/− and cd47 −/− mice, … dw babies\u0027-breath
Thrombospondin-1 promotes matrix homeostasis by interacting …
WebThrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. … WebOct 9, 2024 · We previously showed that TSP1 has an important role in obesity-associated metabolic complications, including inflammation, insulin resistance, cardiovascular, and … WebAug 1, 2024 · The LSKL peptide is a competitive antagonist that inhibits TSP-1-TGF-β activation by preventing the interaction of TSP-1's KRFK sequence with the LAP of latent TGF-β (Fig. 1) [23].This antagonist tetrapeptide has been widely used by our lab and others, along with thbs1 (TSP-1) null animals, to establish TSP-1 as a primary regulator of TGF-β … dw baby\u0027s-breath